Quality the intersection of pneumonia and cause of disease under old age and have illness coming on prevention and health care _ of mechanism

Quality the intersection of pneumonia and cause of disease under old age and have illness coming on prevention and health care, _ of mechanism,
The cause of disease: Too clear to divide into two major kinds according to the cause of disease:
1.The cause of disease has been already bright
(1)Suck the inorganic dust: Oxidize silicon, asbestos, talc, antimony beryllium coal aluminium, tin, iron two times.
(2)Suck the organic dust: Mould grass dust sugarcane dust mushroom lung, ill, cotton dust synthetic fiber bakelite radioactive rays of person who raises pigeon are damaged
(3)The microorganism is infected with: Virus bacterium, fungi, card lung sporozoite's disease, parasite.
(4)Medicine: Malicious chemotherapy medicine of cell, subdueing amine, ring phosphorus amide in vain.
(5)Cancer lymphangitis; Lung edema.
(6)Suck the gas: Oxygen, sulfur dioxide, chlorine oxidize nitrogen, smoke and dust fat mercury vapour
2.The cause of disease has not been bright Person who send the intersection of quality and fiber take among the lung specially ' have another name called latent source, cause fiber take the intersection of alveolus and inflammation, specially quality pneumonia under person who take place) . Acute rooms of quality pneumonia; Take off quality pneumonia among the bits; Collagenic blood vessel disease: Systemic the intersection of lupus erythematosus and the intersection of rheumatoid and the intersection of arthritis and strong straightforward the intersection of backbone and inflammation, multiple myositis - leather myositis give up Glen's syndrome; Tubercle; Organize cell increase disease; - nephritis syndrome that the lung bleeds; Specially sending lung hemosiderin calm disease; Wegener granulation is swollen; Pneumonia of chronic acidophil; The alveolus albumen deposits disease; Hereditary lung fiber; Nodular sclerosis and nerve fibroma; Quality pulmonary tuberculosis among the lung blood vessel beds; Artery high pressure of primary lung; Filling the air a kind of sex change of starch; Stopping up pneumonia of sex of combining machine of thin bronchitis.
The known causes of disease account for 35% of all ILD, the persons who among them regard job contact as the pathogenic cause of disease are common, among them dust of inorganic type is the most for cause of disease person, caused the patient to increase day by day by the dust of organic type. Call anaphylactic alveolus inflammation too due to dust of organic type, , , person who send the intersection of hemosiderin and calm disease wait for secondly speciallyOnset mechanism: ILD precise morbidity mechanism totally expounded yet but ILD of different causes of disease changes begins from alveolus inflammation, cause the fiber inclination of lung to have its something in common in the course of developing and repairing. The macrophages which activate Nan have a function which adjust lymphocytes and secrete the inflammation medium such as alexinic composition, prostaglandin collagenase, neutral protease of elastic hard protease, of fibrinolysin activator the intersection of glucuronic acid and the intersection of enzyme and blood vessel turn into factor, become fibrous the intersection of cell and growth factor and neutral grains of cell hasten, take function such as the factor. Can secrete the lymphokine while activating T lymphocytes, if macrophages move the conduct and inhibit the factor, the leucocyte inhibits the factor, monocyte factor and macrophage of hastening and melting can secrete IgG to activate B lymphocytes such as the factor,etc., Nan's neutral cells such as IgA and IgM can secrete collagenase elastic protease, neutral protease (cathepsin G) Acid protease (cathepsin D) Glucuronic acid of humoral inflammation route of various of enzyme and activation,etc..
1.Pathologic classification
(1)Classify by pathologic change:
It is not that inflammation is not tumour disease: Such as the source anaphylactic granulation swollen alveolus inflammation outside tubercle
Swollen a quality lung disease of granulation: Quality lung edema, the intersection of alveolus and the intersection of albumen and calm the intersection of disease and primary the intersection of lung and the intersection of hemosiderin and calm the intersection of disease and uremia,etc. among being for instance chronic
Lung -specific inflammation: If quality pneumonia and stopping up pneumonia of sex (BOOP) of combining machine of detailed bronchitis among general type Other source stimulating the intersection of smog and liquid and other toxic quality pneumonia, acute to breathe poverty-stricken syndrome (ARDS) under chronic irritation Specially sending lung fibers and vascular inflammation of the lung,etc..
Inorganic dust sucking occupational disease
Hyperplasia and tumour pathological change: If primary detailed bronchus alveolus cancer brings out pathological change of the quality, filling the air Hodgkin's lymphoma among the lung
The intersection of quality and fiber take among the lung and the intersection of honeycomb and lung .
(2)Classify according to the cell type gathered in the alveolus structure:
Macrophage - lymphocyte - neutral cell types: Abbreviated as neutral grains of cell type alveolus inflammation. Macrophages still take the majority but neutral cells increase and assemble in the alveolus structure for a long time, it is originally type most typical characteristic. Pathological change which belongs to one type this is as follows, person who send the intersection of lung and fiber take specially Quality the intersection of lung and fiber take companion, take place on collagenic blood vessel disease, organize the intersection of cell and the intersection of hyperplasia and the intersection of disease and X and the intersection of asbestos and lung,etc. among family the intersection of lung and fiber take chronic.
Macrophage lymphocytes type: Abbreviate lymphocyte the intersection of alveolus and the intersection of inflammation and macrophage as and lymphocyte increase and the intersection of lymphocyte and increase of Nan increase tubercle than the intersection of macrophage and many the intersection of Nan and neutral grains of cell relative Disease, anaphylactic pneumonia and beryllium are poisoned etc., belong to one type this.
Lung essence cells are acted on by a certain directness of causing the cause of disease to be plain, or acute alveolus inflammation happens at alveolus inflammation stage through the fact that the indirectness of inflammation and immune cell system act on, its pathological change can be reversed such as removing the cause of disease or receiving treatment; As acute alveolus inflammation transfers to chronic neutral cells to secrete collagenase and elastic protease destroying collagen and alveolus wall, the ones that influenced pathological change are reversible. Develop if pathological change further,among last disorder mirror collagenous thread examine to can see to organize hyperplasia alveolus not to be separated to destroy a large number of fiber at quality, the alveolus wall forming the bag fiber and destroying can't recover; Pathological change further develops into alveolus structure and totally damages and forms the extensive bag fiber
2.A quality pulmonary tuberculosis is by stages:
One: Lung the intersection of essence and cell damage, take place acute getting scorching alveolus and immune the intersection of effect and cell present hyperplasia, raise and activate phenomenon.
Verify while irritating lotion that there is immunity that compounds the body Nan in specially sending lung fiber bronchus alveolus, can stimulate macrophages to secrete neutral cells and trend towards the factor of melting, make neutral cells assemble in the alveolus structure. Activatory macrophage and neutral grains of cell can secrete the intersection of collagenase and the intersection of Nan and the intersection of bronchus and alveolus, irritate, wash, follow up a case by regular visits to, reexamine collagenase activity store in continuously still 8- 24 months, activatory collagenase can destroy quality among alveolus structure collagen (in acute pneumonia such as pneumonia coccus pneumonia Nan, neutral grains of the intersection of cell and Nan time that store in very transient in the intersection of alveolus and structure, so will not cause a quality to form and form organizing and permanent damage. )Person who send fiber take and the intersection of tubercle and the intersection of disease and the intersection of bronchus and alveolus irritate macrophage that isolate train Nan produce fiber combine egg in having the intersection of RPMI-1640 and culture medium separately in the lotion specially White speed differentiate 20 times faster and 10 fibrous conjugated proteln to the intersection of lung and becoming fibrous cell have, hasten, take than normal macrophage the intersection of function and Nan form rooms of the intersection of quality and fiber take, get up dirty Important the intersection of function and the intersection of tubercle and lymphocyte, T of disease, can secrete lymphocytic to sharpen, cause granulation to be swollen to form at a stage usually, lung damage of essence Nan stimulate factor, dispel into Nan's pathological change, can resume while being obvious.
2One: The non- cellulous and cellulous composition that alveolus inflammation develops into the chronic alveolus is damaged, and (or) Split up property change Nan. Type, damaging, in 2 mend to develop to 2 stage cell hyperplasias leather from issue cells leathers upper, or whether quickly or the slow elder can be up to several years and if contact time limit by various factors, the lung is dirty to defend mechanism's efficiency to damage the range size, integrality and individual Nan of basilar membrane to influence the intersection of alveolus and destruction of structure turn into irreversible Nan seriously gradually.
One: The intersection of characteristic and the intersection of quality and collagenic the intersection of disorder and Nan among being its, mirror examine can be seen, organize hyperplasia by a large number of fibers. The fiber because activates as fibrous cells simply while organizing hyperplasia, that various compound factors such as collagen is formated with all kinds of cells unusually causes. Collagen organize the intersection of fracture and alveolus separate, destroy, form bag nature change. It has been already impossible that damage and prominent disorder of the greater part demobilized that an alveolus arrives structurally.
A Nan: It is the advanced stage of this disease. The alveolus structure is totally damaged, can't be recognized basic structure and characteristic of all kinds of quality fibers instead of the filling the air bag change without function
Demarcation line of every of the above very difficult to divide completely, and can overlap each other
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