Unite _'s prevention and health care of using medicine of first class prevention of effective HIV the infeted's very inactive pneumocystics carinii pneumonia of antiviral treatment

Unite _'s prevention and health care of using medicine of first class prevention of effective HIV the infeted's very inactive pneumocystics carinii pneumonia of antiviral treatment
Unite the first class prevention of effective HIV the infeted's very inactive pneumocystics carinii pneumonia of antiviral treatment and use medicine

Number 14 of 26 rolls in total April 13, 2000 of number 708 of China's medical Tribune

Reports such as Swiss Furrer,etc., prospective formation study, prove, resist, go against, duplicate the intersection of virus and the intersection of treatment and effective inactive pneumocystics carinii pneumonia, the infeted of HIV, it prevents administration to be safe jointly.

Keyword:HIV infects It is antiviral to unite Pneumocystics carinii pneumonia First class prevention

Pneumocystics carinii pneumonia mainly happens in CD4+Lymphocytes are counted and dropped to 200 mm3The following HIV infect patients, it is estimated that its morbidity is 20 100 patients - annual. Mouse's encephalitis of bow-shaped body incident of the positive one of bow-shaped body IgG antibody of serum, CD4 lymphocyte counted
Jointly employing and resisting and going against it after duplicating virus medicines, most patients can reduce the blood plasma HIV rNA level within several weeks and increase CD4 cells to count. Can also reduce the morbidity that HIV the infeted's chance infects in later period at the same time. But antiviral to treat the intersection of HIV and the infeted that succeed jointly, inactive pneumocystics carinii pneumonia can be so obvious at present in administration in first class prevention. Furrer,etc. adopt prospective the intersection of formation and research approach, assess, accept, resist HIV that treatment succeed inactive to prevent from the security using medicine in the infeted against duplicate virus.

Include it in the target of this research in order to accept that jointly resists to go against to duplicate the effective HIV the infeted of virus treatment, its CD4 cell is counted and increased to 200 mm during uniting the antiviral treatment3The above accounts for 14% of the total number of lymphocytes, and keep for 12 weeks at least. Inactive to reexamine once every 3 months after preventing from using medicine. Study in the terminal in order that pneumocystics carinii pneumonia or bow-shaped body encephalitis happens.

The result reveals, 121 (46.2%) while including in in the infeted of 262 HIVs Patient's mouse's bow-shaped body IgG antibody is positive. The base-line CD4 cell median is 325 mm3(The range is 210- 806/mm3),The lowest CD4 cell median is 110 mm3(The range is 2- 240/mm3). The median is 11.3 months to follow up a case by regular visits to time. 9 patients resume employing and resisting pneumocystics carinii pneumonia to prevent from using medicine, 2 die, but pneumocystics carinii pneumonia and bow-shaped body encephalitis happen in the same way. Pneumocystics carinii pneumonia morbidity for 1.9 cases 100 patient - it is annual (can believe by block upper limit for 99% times, the single side is examined) ; The corresponding value of encephalitis of bow-shaped body is 4.2 100 patients - annual.

In a word, accept and resist against HIV the infeted duplicating the virus and jointly treating, if its CD4 cell is counted and maintained at 200 mm continuously3The above and accounts for more than 14% of the total number of lymphocytes, the first grade of inactive pneumocystics carinii pneumonia prevents the administration from seeming to be safe.



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