Liver kidney syndrome and liver _ general knowledge of encephalopathy

Liver kidney syndrome and liver _ general knowledge of encephalopathy
Liver kidney syndrome, it is depleted to also call the functional renal function, refer to disease patient's damage of supersession product in the body of serious liver, the change of dynamics of blood and abnormal state of blood flow volume, causing reduction and filterability of renal blood flow volume to reduce causes, its kidney has not been dissected and pathological change of the histologic respect.

The clinical manifestation of liver kidney syndrome includes liver cirrhosis loses symptom and physical sign which compensates two respects of one and functional renal failure. The patient often has pulse hyperbarism of doors, splenomegaly, a large amount of ascites, jaundice, nitrogen blood disease, few urine, hyponatremia disease,etc..

Materials statistics show nearly there are 70%- 80% of the patients that present the nitrogen blood disease in later period in liver cirrhosis. The main manifestation of liver kidney syndrome is as follows:

(1)Shown as and lacked the urine in early days, the ones that continued had no urine and nitrogen blood disease appears. Get up disease to be very worried and sudden, can also comparatively latent to attack.

(2)Most patients have a large amount of ascites and jaundice, jaundice can fluctuate greatly, severe ascites and jaundice appear finally.

(3)Patient's symptom is aggravated gradually, is shown as that there are no urine, blood pressure to reduce to lose the appetite, weak, sick, vomit, have a liking for sleeping, few urine, sustainable from several days to several weeks, to treating reaction difference.

(4)More than half patient can amalgamate and present liver encephalopathy.

(5)It is very normal to check the early urine, there can be micro- albumen, red leucocyte and in charge ofing type on a small quantity in middle and later periods, its characteristic is contrary to uremia due to nephritis.

(6)Only a few liver kidney syndrome patients are right to treat effectively, the majority is aggravated continuously, until dying.

Liver encephalopathy whether liver function damage seriously, can't until poisonous metabolite detoxify in the blood; Or because the intersection of door and vena cava shunt postoperative, portal vein hit noxious substance detoxify by liver, enter systemic circulation directly through the collateral circulation, cause the supersession of central nervous system to be disorderly, regard changing and going into a coma in consciousness as syndrome mainly displayed. The brain function obstacle including reversible supersession encephalopathy, chronic and irreversible brain structure of brain edema changes.

Mechanism's most important hypothesis is that liver encephalopathy has illness coming on: Ammonia hypothesis (liver encephalopathy is because the neural toxin of ammonia acts on) , in coordination with the toxin hypothesis (other toxin strengthen ammonia toxicity) , " false neural medium " The hypothesis (can damage dopamine because the brain of blood of fragrant amino acid shifts to increase the ganglion is conducted) Sour (GABA) with 's ammonia junket Hypothesis (infer the tension of this kind of inhibiting from medium system of nerve transmission increases, excitement buy body cause by getting endogenous the intersection of benzene and third two the intersection of nitrogen and ) .


|