Common indication of liver transplantation - - prevention and health care of liver cirrhosis after hepatitis

Common indication of liver transplantation - - prevention and health care of liver cirrhosis after hepatitis
Chronic B-mode, chronic C-mode and chronic man type hepatitis can cause liver cirrhosis. Man type B-mode hepatitis virus of hepatitis virus' reliance duplicates and expresses, so it infects and only happens in the hepatitis B patient. The B-mode hepatitis virus is through inducing one's own immunity of the organism to do harm to hepatocyte, and chronic hepatitis C and chronic man type hepatitis result from the reason that the virus causes the primary hepatocyte to damage.
Our country is the height sending area of hepatitis B, the B-mode person who carries hepatitis virus accounts for 10% of total population, there are more than 30 million hepatitis B patients at present. Among them in HBeAg continuously positive chronic hepatitis B patient, the liver cirrhosis can take place in 50%, liver cirrhosis seldom takes place to HBeAb positive patient. Liver cirrhosis patient develop, lose, compensate as condition issue appear often one or more serious liver function depleted (liver is declined) With complication of portal vein hyperbarism, if is malnutritive, low albumen blood disease, blood coagulation function obstacle, obstinate ascites, oesophageal fundus of stomach taking place repeatedly are variceal to break bleeding and liver encephalopathy, liver kidney syndrome etc.. Have 40% the intersection of liver cirrhosis and patient disease die of various complication at last, so liver cirrhosis lose compensate issue walk liver it transplants to be the intersection of our country and main the intersection of adaptation and card behind the hepatitis B. Because the B-mode hepatitis virus often exists in other cells beyond the hepatocyte, used to perplex, it transplants doctors and issues of patient to be, patient expert at liver transplant, often appear and transplant the B-mode hepatitis virus (HBV) of liver while being postoperative Infection again,it is which cause hepatitis for recurring liver function it even transplant lose. If HBeAg is positive or HBV-DNA is positive before the skill, on the premise of not having any precautionary measures, the recuring rate of postoperative hepatitis B can be with up to 80%. So it is not very ideal to transplant the result in early days.
In recent years, because of hepatitis B and immunoglobulin (Ig) (HBIG) With the intersection of Lammi and that make preventative application, liver transplant postoperative HBV the infection rate drops notably and then, its patient's life cycle and patient of other types are roughly the same. HBIG is that the first is proved effective preventing the liver from transplanting the medicine that postoperative HBV infected again clinically, but function its have obvious the intersection of quantity and the intersection of result and relation, transplant, use HBIG over 6 months in a large amount for a long time while being postoperative in liver only, could make the liver transplant the infecting and reducing to 10% on average of HBV in 2 years after the operation, thus lengthen the survival period transplanting the liver. Employ HBIG can make 10%- 20% patient appear HBsAg encode gene mutation of district, lead to the fact HBIG and affinity that HBsAg combine drop and present, able to bear medicine too for a long time. Single the intersection of Lammi and make, too can make liver transplant HBV the infection rate is lowered to 20% and then in the 1 year after the operation, basically about equal with employing the therapeutic effect of HBIG for a long time, the subject problem is Lammi the makes YMDD of the inducible HBV polymerase code district and makes a variation, recurring of one of causing the B-mode hepatitis virus and making a variation. So a lot of scholar think HBIG with the intersection of Lammi and it unites administration to be to prevent best scheme that HBV is infect again definitely, the experience proves that can control the infection rate again below 10%. Kindness Wei to resist the intersection of HBV and most effective medicine at present for card, it already can treat HBV infection and then that cause employ the intersection of Lammi and definitely, can should use, prevent the liver transplant postoperative HBV and is infected with as a gleam of medicine.
The patient of liver cirrhosis after hepatitis C, the condition develops to latter stage of end, need to rely on liver transplantation to save the life too, the survival rate can reach 62% in postoperative 10. Hepatitis C is here postoperative recur too, the recuring rate, about 20%, in that 12%-16% of the patients do not only have any clinical symptom and test unusually for C-mode person who carries hepatitis virus, it is too unusual to have any clinical symptom that 60%-70% of the patients only have slight laboratory test, 4%-27% of the patients can present various clinical symptoms of intensity, but it is 8%-10% of the patients that will develop within 10 years into liver cirrhosis to need the liver to transplant again. Hepatitis C recuring rate most high with the intersection of Model HCV1b and virus, but survival rate, with having obvious difference to compare to infect the group of 5 years.
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