The result of laboratory test of liver function is solved completely

The result of laboratory test of liver function is solved completely
The purpose to check on clinic in liver function lies in whether there is disease to survey the liver, extent of damage of the liver and finding out the hepatopathy reason, judging the prognosis and distinguishing that the cause of disease of jaundice takes place etc.. Liver function is in many aspects, it is very complicated at the same time. Because the liver is compensated very capably, in addition, there is no specific and strong, high, including liver function detection method that the range is wide of sensitivity yet at present, therefore can't get rid of liver pathological change even if liver function is normal.


At present, the test that liver function launches on clinic is various in style, not less than dozens of kinds, but every kind of liver function test can only ascertain a certain function in a certain respect of the liver, have not had a kind of tested that can reflect the repertoire of the liver yet till now. So, in order to obtain the objective liver function conclusion, should choose many kinds of liver function test associations, want numerous check if necessary. While appraising the result of liver function test, must combine clinical symptom and consider liver function in an all-round way at the same time, avoid one-sidedness and subjectivity.

Because of the difference between laboratory condition of each hospital, attenbant, detection method, examine with liver function that hospital offer normal value consult range to be generally different even. The normal value that we no longer enumerate each project consults the range here, Chinese name, English code and any main clinical meanings are introduced of each project.


Reflect the project that the hepatocyte damages

Measure commonly usedly with serum enzyme, include third amino acid amino transferase (commonly called as GPT ALT) , the amino acid amino transferase (commonly called as transaminase AST of millet straw) of winter of door , alkaline phosphatase (ALP) , - valley ammonia acyl is transferred to peptide enzyme ( - GT or GGT) When. In various enzyme tests, ALT and AST can reflect whether the hepatocyte is damaged or not and damaged the intensity sensitively. When various acute virus hepatitis, medicine or alcohol cause the acute hepatocyte to damage, serum ALT is the most sensitive, ALT rises sharply before clinical symptom such as jaundice appears, AST raises too at the same time, but AST raises the intensity and is not so good as ALT. In chronic hepatitis and liver cirrhosis, AST raises the intensity to exceed ALT, so AST mainly reflects the liver damages the intensity.

At the in weight disease and hepatitis, because of a large number of hepatocyte necrosises, ALT drops gradually in the blood, but bilirubin person who go on rise at this moment, namely appear" enzyme of gallbladder separate" The phenomenon, this is often an omen of liver necrosis. Acute convalescence such as hepatitis, appear normal ALT and - GT rise continuously, brief hepatitis on to be chronic to take often. While suffering from chronic hepatitis if - GT continuation exceeds the consulting value normally, it is in activity one to point out chronic hepatitis.


Reflect the project that the liver secretes and excretes the function

Including total bilirubin (TBil) , direct bilirubin (DBil) , total bile acid (TBA) ,etc. determination. Act as and suffer from virus hepatitis, medicine, or when that alcohol cause poisoning hepatitis, dissolve courageous and upright jaundice, pernicious anemia, popping hemoglobinuric disease and neonatal jaundice, internal haemorrhage,etc., can all raise total bilirubin. Direct bilirubin means after the liver is dealt with, the part in combination with glucuronic acid base in total bilirubin. Direct bilirubin raise, explain hepatocyte, deal with discharge after the bilirubin, the obstacle takes place, namely the biliary tract happens to obstruct. Determine TBil and DBil at the same time, can differential diagnosis dissolve courage and uprightness, the intersection of liver and cellulous and obstructive jaundice. Dissolve courageous and upright jaundice: General TBil85 mol/L, direct bilirubin total bilirubin 20%; Cellulous jaundice of the liver: General TBil200 mol/L, direct bilirubin total bilirubin 35%; Obstructive jaundice: General TBil340 mol/L, direct bilirubin total bilirubin 60%.

In addition - GT, ALP, 5 ' - nucleotide (5 ' - NT) Also very sensitive the intersection of reflection and enzyme that bile deposit, rising of them brief on, may appear biliary tract block disease of mainly.


Reflect the liver formates the project which stocks the function

Including the previous albumin (PA) , albumin (Alb) , choline esterase (CHE) With the time of thrombinogen (PT) When. They reflect its regular test of stocking ability by measuring the liver and formating the function. It is weakened that the previous albumins, albumins drop to brief on the ability of a synthetic protein of the liver. When suffering from various hepatopathy, the more serious the condition is, the lower the choline esterase activity of serum is. If the choline esterase activity reduces and not rebounds the sign continuously, brief on more prognosis badly. ALT and GGT rise at the time of disease in the liver and gallblader, if the person who reduces CHE, as liver illness at the same time, and the normal one is mostly biliary tract diseases. In addition CHE can be seen Yu JiaKang, diabetes, nephropathy and syndrome and fatty liver while increasing.

Time of thrombinogen (PT) Extension announces the liver formates the ability of different blood coagulation factors to reduce.


Reflect the liver fiber and project of liver cirrhosis

Including the albumin (Alb) , total bilirubin (TBil) , single amine oxidase (MAO) , blood albumin is electric swimming,etc.. When the patient suffers from liver fiber or liver cirrhosis, will reduce serum albumin and total bilirubin, rise with single amine oxidase at the same time. The intensity that globulin increases can comment on development and prognosis of the chronic hepatopathy in the electric swimming of albumin of blood, point out witheredly and deny the cell function and fail, can't remove the endogenous or source antigenic material of intestines in the blood circulation.

In addition employ a more one transparent quality sour (HA) at clinic recent years , layer sticks albumens(LN) , type ago collagenic peptide sum collagen. Determine their serum content, can reflect liver endothelial cells, store lipoprotein cells and become the change of fibrous cells, if the intersection of serum and level of them raise, brief patient on, might have the intersection of liver and the intersection of fiber and take and liver cirrhosis often.


Reflect the serum mark of liver tumour

At present may be use for diagnosing biochemistry of the primary hepatocarcinoma examines only first child albumen (AFP) of index . First child albumen uses for the diagnosis in early days of hepatocarcinoma at first, it has already risen in 8 months before a patient presents symptom in hepatocarcinoma, most hepatocarcinoma patients do not still have obvious symptom at this moment, these patients are after surgery treatment, the prognosis gets obvious improvement. First child albumen used in the intersection of hepatocarcinoma and the intersection of operation and monitoring of curative effect widely still and following up a case by regular visits to postoperative, and high-risk group follow up a case by regular visits to now. But first child albumen will rise under situations such as normal and pregnant woman, a few hepatitis and liver cirrhosis, gonadial malignant tumour,etc., but the raised range is less high than primary hepatocarcinoma. In addition, some hepatocarcinoma patient first child albumen values can be normal, so should carry on the image at the same time and study inspection such as Ultrasonography B, CT, magnetic resonance (MRI) With liver angiography,etc., the dependability diagnosed by this increase.

It is - L - rock algae candy glucoside enzyme (AFU) that is worth putting forward ,The positive rate diagnosed to primary hepatocarcinoma that serum AFU is determined is among 64%-84%, the specificity is about 90%. AFU, with their to the intersection of detection and light high sensitiveness of hepatocarcinoma, to predicting cirrhosis erupts the high specificity of hepatocarcinoma simultaneously, with the good complementarity that is determined with AFP, the indispensable means that and is being recognized as hepatocarcinoma and diagnosed, followed up a case by regular visits to and cirrhosis is being guarded. The intersection of serum and AFU live determine, have some overlap among the hepatocarcinoma, lung cancer, breast cancer, ovary or uterus cancer in some transformation in addition, it is not even that tumour illness such as liver cirrhosis, chronic hepatitis and digestive tract bleed etc. and rise slightly in some, so should pay attention to distinguishing.

Liver function is in many aspects, it is very complicated at the same time. Because the liver is compensated very capably, in addition, there is no specific and strong, high, including liver function detection method that the range is wide of sensitivity yet at present, therefore can't get rid of liver pathological change even if liver function is normal. Especially damage in the liver in early days, a lot of patient liver function test results are normal, only will present the abnormal state of the test result of liver function when the liver is damaged to reach certain intensity. The test result of liver function will be influenced by many kinds of factors such as experimental technique, experiment terms, reagent quality and attenbant too at the same time, so the test result of liver function should be combined factors such as clinical symptom,etc. by the clinician and carried on comprehensive analysis, then confirm whether there is disease, need treating and monitoring.

Chronic hepatopathy, especially chronic hepatitis B have unusual liver function more, need recuperating for a long time, it is essential to protect the liver. In recent years, the free-radical role in hepatopathy has already been paid close attention to by domestic and foreign expert, especially free radical removes pharmaceuticals and protects the relevant research of the liver to deepen more and more, the method of rehabilitation of hepatopathy has made new progress too.


Liver work Laboratory test
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