Meaning _ checking the index in liver function tests the inspection

Meaning _ checking the index in liver function tests the inspection
It is the important index of diagnosing hepatitis B that liver function is checked. Checking the project in commonly used liver function has third amino acid transaminase (ALT) Or valley - third transaminase (GPT) , the amino acid transaminase (AST) of winter of door Or valley - transaminase of grass (GOT) , alkaline phosphatase (ALP) , - valley ammonia acyl is transferred to peptide enzyme (GGT) , total bile acid, albumin globulin (A/G) , total bilirubin (T-Bil) With direct bilirubin (D-Bil) . Normal value and clinical meaning of the index of the liver function are as follows.
1.ALT and AST:
ALT and AST are mainly distributed in the hepatocyte of the liver. The normal value is 0- 40 international units. If hepatocyte necrosis, ALT and AST will rise. Its raised intensity conforms with intensity that damage the hepatocyte, so is the most frequently used liver function index at present. The distribution in the hepatocyte of these two kinds of enzymes is different. ALT is mainly distributed in the cytoplasm of liver, AST is mainly distributed in cytoplasm of liver and mitochondria of the hepatocyte. So, ALT and AST raised intensity and ratio of AST/ALT of different kinds of hepatitis patients are different. Acute hepatitis and chronic hepatitis and light, although there is damage of the hepatocyte, mitochondria of the hepatocyte still keeps intact, so release ALT that only exists in the cytoplasm of liver which enters the blood, so, liver function is mainly shown as the rising of ALT, then the ratio of AST/ALT 1, even> 2. Patient of alcohol hepatopathy, the activity of AST is often greater than ALT too.
2.ALP and GGT
Alkaline phosphatase (ALP) Transfer with - valley ammonia acyl to peptide enzyme (GGT or - GT) Diagnose the index that systematic disease of the biliary tract often uses.
Alkaline phosphatase nearly exists in each tissue of the organism, but more with skeleton, tooth, liver, renal content. Alkaline phosphatase in normal people serum mainly comes from the skeleton, is produced as bone cells, pass from blood to the liver, excrete from the biliary tract system. So, this enzyme obviously rises when obstructing outside silt gallbladder type hepatitis and liver.
- valley ammonia acyl is transferred to peptide enzyme and distributed very widely in the body, for instance internal organs such as the kidney, liver, pancreas,etc. have this enzyme. But - valley ammonia acyl in serum is transferred to peptide enzyme and mainly come from the liver, so have stronger specificities. At the time of systematic disease of the liver and gall, this enzyme rises. During hepatitis convalescence, after ALT and AST have already returned to normal, - valley ammonia acyl is transferred to peptide enzyme and does not drop to yet normally. So, often regard this enzyme as the sign whether a patient can resume normal work at present. The patients GGT of alcohol hepatitis and obstructive jaundice obviously rise.
3.Albumin globulin (A/G)
The albumin is made in the liver, when liver function is damaged, the albumin reduces, it is parallel that it reduces intensity and severity of hepatitis. Chronic and heavy-duty hepatitis and density of serum albumin of liver cirrhosis patient are reduced. The albumin plays nutrition cells and keeps permeating the function pressed in the blood vessel in the body. When the albumin reduces, permeate and press to reduce in the blood vessel, patients can present the ascites. Globulin is that the immune organ of organism is made, there are antigen (enemy) such as virus to work as the body When, the immune organ of the organism will throw in more troops soon, to eliminate the enemy. So, globulin increases. Chronic hepatitis and the liver cirrhosis patient's albumin reduce, and globulin increases at the same time, cause A/G ratio to invert.
Normal value FONT of the serum albumin >
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