Liver _ general knowledge of encephalopathy

Liver _ general knowledge of encephalopathy
Liver encephalopathy is the manifestation in latter stage of end of hepatocarcinoma, causing the main causes of death of hepatocarcinoma (about 35%) . Liver encephalopathy whether the intersection of cancer and organization damage the intersection of liver and essence or amalgamate liver cirrhosis, lead to the fact the liver essence to destroy extensively at the same time due to seriously often. Upper digestive tract bleed, infect with and the intersection of hypokalemia and disease, operation attack, release, put improper ascites and should use a large amount of diuretic and medicine to impair liver liver encephalopathy

Common inducement. Can only prevent and cure to its inducement at present, still lack the effective treatment. Because the condition is relatively late, it is rarely seen to treat the winner.



The morbidity mechanism of liver encephalopathy is not still clear at present, may relate to some following factors:



(1) Ammonia is poisoned the theory

Under the normal situation, production of ammonia, with remove, keep dynamic equilibrium, thus make the intersection of blood and ammonia water keep normally while being flat. When liver function is severed, it is flat for ammonia water of blood to rise. It raise blood can ammonia be increased to be turned into or ( Sum) It is enough for ammonia to drive out ' Ornithine circulates the obstacle) Due to.



(2) False neurotransmission theory

The catecholamine such as noradrenaline and dopamine is the normal neurotransmission in the nervous system, usually the catecholamine in the blood can't pass the blood brain protective screen, so the inner catecholamine of brain must rely on nerve fiber to formate. Amino acid such as the benzene third amino acid and hydroxyphenylaminopropionic acid with benzene ring in protein diet, they can form benzene second amine and junket amine while being by bacterium to take off slope, act on in intestine, by people's liver of portal vein after this kind of biological amine is absorbed by the intestine.



(3) Out-of-balance theory of amino acid of blood plasma

Under the normal situation, the content of various amino acids in blood plasma keeps more appropriate proportion. AAA (fragrant clan amino acid) Enter cells in a large amount, make the false neurotransmission produce and increase and and inhibit the formation of the normal neurotransmission, cause the emergence of liver encephalopathy finally. The out-of-balance theory of amino acid of blood plasma is the supplementary and development of the false neurotransmission theory.
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