Hepatitis liver cirrhosis and hepatocarcinoma concern _'s general knowledge

Hepatitis liver cirrhosis and hepatocarcinoma concern _'s general knowledge
Liver cell cancer ( Abbreviated as hepatocarcinoma) It is one of the common malignant tumour in our country, accounts for the second of mortality of malignant tumour. Near diagnosis and treating competence to improve a lot on the original foundation of hepatocarcinoma of our country for over ten years, and already made the achievement of world interest.
Relation of first, hepatitis and hepatocarcinoma
A large amount of epidemiology is investigated it already proves B-mode, C-mode virus hepatitis has been closely linked to emergence of hepatocarcinoma to study with the experiment. This has already been generally acknowledged by people, but its carcinogenic mechanism is not so obvious so far. The carcinogenic mechanism of HBV, the view thought to contain the cancer gene in HBV genome in the past has been denied for a long time. The mechanism regarding HBV activates and starts the son or strengthens the son after combining also fails to be verified. Think X gene is closely related to emergence of hepatocarcinoma in recent years; HCV is a kind of RNA virus, according to discovering recently HCV key protein has potential carcinogenic function outside the body. Clinical finding, most hepatocarcinoma patients have hepatitis and liver cirrhosis medical history previously. The persons who hepatocarcinoma takes place in liver cirrhosis are 15%-25%, it is generally about 20%, most hepatocarcinoma happens on the basis of liver cirrhosis after hepatitis.
Second, how does the liver cirrhosis develop into hepatocarcinoma?
The main pathology of hepatitis is changed into inflammation, necrosis and fiber of the liver, some downright bad intensity serious such as the intersection of piece and necrosis, the intersection of bridge graft and necrosis,etc., liver fiber take, stretch the intersection of liver and little leaf into remitting areaing under control thereupon, form the small false leaf gradually, produce regenerated tubercle. The emergence of hepatocarcinoma is closely related to regenerated tubercle. Most scholar think adenoma hyperplasia for pathological change in front of the hepatocarcinoma, can develop into hepatocarcinoma by many step: Big regeneration tubercle --Adenoma hyperplasia --Atypical adenoma hyperplasia --Adenoma hyperplasia worsens the hepatocyte on a small quantity --It is good to split up(I grade) Early hepatocarcinoma.
The emergence law of most hepatocarcinoma is summed up as follows: HBV, HCV, alcohol is other ----Chronic hepatitis ' Inflammation, necrosis, liver fiber) ----Liver cirrhosis( Tubercle forms, different type becoming, adenoma hyperplasia) ----Hepatocarcinoma




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