What long _'s general knowledge does the natural course of disease of hepatocarcinoma have

What long _'s general knowledge does the natural course of disease of hepatocarcinoma have
Has always thought the course of disease of hepatocarcinoma very short, does not usually exceed 6 months, with first child globulin (AFP) Wide application measuring and progress of different localization methods, the detection of 1- 2c m small hepatocarcinoma, make people have new understanding on natural course of disease of hepatocarcinoma. The soup of medical university of Shanghai in 1981 encourages the new concept that You put forward the natural course of disease of hepatocarcinoma.
The natural course of disease of the primary hepatocarcinoma can be divided into 4 stages:
(1)Early inferior clinical one: Namely begin by having illness coming on and diagnose establishment to inferior clinical hepatocarcinoma. If from the moment that AFP become abnormal in accumulating first, the time of location of China is about 10 months (reality may be longer) ,Namely tumour is long to can be measured to orient the means at present (namely 1- 2c m ) Necessary time ago. During this except that it does not have any and unusually can be seen that AFP low density rises. Diagnose and it is still difficult to make a reservation in early days.
(2)Inferior clinical each) : Namely diagnose from inferior clinical issues of hepatocarcinoma that establishes appearing to symptom (about 8- 9 months) . The patient of this inferior clinical hepatocarcinoma does not have any symptom and physical sign, diagnose that mainly depends on measuring AFP, Model B supersonic wave, CT to check etc.. This tumour is relatively little, there are many chances excised in operation, about 90% can obtain early tumour to excise, survival rate can reach 90% about 5 year excise, brief on, at, can cure stage and have, spread obviously still by most the intersection of case and disease their.
(3)Middle period period) : Mean the appearance that shifts from the physical sign of symptom to the jaundice, ascites or distant place, about 4 months. Overwhelming majority of scanning etc. such as this every inspection become abnormal, so diagnose that there is not a difficulty yet. The patient operation excise and survival rate have only 20% to be about 5 year, brief on, have tumour to spread by most patients. Can have discovered the portal vein and already to check had cancer bolts while propping up in Ultrasonography B and CT. The diameter of location has already reached 9- 10c m in this tumour.
(4)Later period period) : Mean appearance shifted in jaundice, ascites, distant place is only about 2 months to the death. This therapeutic method that has already lacked the effective extension patient's life. The portal vein backbone cancer bolt generates an important impact on irreversible disease course.
So, primary hepatocarcinoma has a quite long natural course of disease, at least more than 2 years. Because when it is unusual to present AFP in the blood, tumour has already developed into certain size, in fact the emergence time of tumour should be earlier.
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