The man function of liver cirrhosis weakens _ symptom of syndrome

The man function of liver cirrhosis weakens _ symptom of syndrome
[Sum up ]
Syndrome that the man function of liver cirrhosis fails, are also called the endocrine to lack - cirrhosis syndrome Silvestrini-corda syndrome. Its main clinical characteristic is that male breast development appears on the basis of cirrhosis, the testis withers and fails etc. and behaves with the function. This evidence is comparatively common, men far exceed women.
[Diagnose ]
Determine serum hits E2, E3 level and increases, ketone of testis and supersession product reduce. Appear male the intersection of breast and development wait for the intersection of gonad and behavior that function fails make diagnosis on the basis of liver cirrhosis.
[Treat the measure ]
It is therapeutic that the treatment of this disease mainly has illness coming on for the liver, lightening with having illness coming on originally, improvement of liver function, the male gonad function can take a favorable turn gradually. Also there are reports to employ the grand sex hormone treatment there may be certain curative effect.
[Pathogenesis ]
Because the deactivation ability of estrogen drops, turns with androgen into estrogen ability, increases at the time of liver cirrhosis, make the estrogen level in the blood rise and excrete and increase with the urine. The increase of the estrogen level can be inhibited hypothalamically through feedbacking function - the hypophysis - gonad axle leads to the fact gonadotropin and ACTH are secreted and reduced, androgen is secreted and reduced, and cause men to be womanlike.
[Clinical manifestation ]
Shown as and increased the male breast gradually on the basis of liver cirrhosis, very it is single side can also dual side,it is meet more not to regard right side as, if you can't take the form of by nipple or tubercle form that milk faint, rise when slightly, similar breasts of women of the heavy one, can have bloated pains, but there is no milk to secrete. In addition have male testis that withers, pubes rareness, sexual desire fail, the sound attenuates, spider moles and liver palms due to often expanding with the skin capillary. The behavior that women patient's estrogen increases is often not obvious, there can be menoxenia, amenorrhea, infertile and functional uterus and bleed.
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