Liver cirrhosis and _'s general knowledge of relation of hepatocarcinoma

Liver cirrhosis and _'s general knowledge of relation of hepatocarcinoma
There are close relations between liver cirrhosis and emergence of hepatocarcinoma. Especially in our country, amalgamate liver cirrhosis at various degrees above the hepatocarcinoma patient 80%. Most liver cirrhosis was developed by chronic hepatitis B. The infection of the long-term hepatitis virus causes immunity of the organism to drop, can't dispel the virus, cause repeated hepatocyte necrosis, hyperplasia, evolve into liver cirrhosis finally. In the outgrowth course of hepatocyte, can present a kind of hyperplasia of cooking stove adenoma of the office, apt to is effected by carcinogenic factor and the canceration takes places, thus develop into hepatocarcinoma. Certainly, it is not the liver cirrhosis patient that hepatocarcinoma will take place, only when immunity of the organism is low, when being not enough to dispel the hepatocyte cancerating, hepatocarcinoma will happen.
Can the stale food cause hepatocarcinoma
The intersection of epidemiology and investigation find hepatocarcinoma occur frequently on warm moist apt to breed yellow the intersection of song and district of mould, especially the area where there are many edible corn, peanut. Animal's experiment proves, mould corn and mould peanut produced by the pollution of aflatoxin can cause hepatocarcinoma, this product yellow aspergillus toxin B1 of supersession of the aflatoxin (AFB1 ) There is strong carcinogenic function. Measure AFB1 and AFM1 to brief on by ELISA method, AFB1, AFM1 correlate with mortality of hepatocarcinoma. And the main source of AFB1 is corn and peanut oil. The recipe investigation reveals, the mortality of hepatocarcinoma is correlated with eating the corn, peanut and peanut oil, and have nothing to do with rice, fruit, vegetables, protein and cellulose. Because of yellow aspergillus toxin (AFT) Caused mutation, caused lopsided, carcinogenic function, the international cancer centre determined AFT as carcinogenic pharmaceutical formally in 1990. That is worth paying attention to is that yellow aspergillus toxin is not the only carcinogenic factor of hepatocarcinoma, many materials reveal, yellow aspergillus toxin and HBV have cooperative effect. If our country makes the experiment with the tree , HHBV is negative, AFB1 is negative the control group has not found hepatocarcinoma (0%) ; The intersection of HHBV and negative, the intersection of AFB1 and negative the intersection of group and 1/9 of the hepatocarcinoma; HHBV is negative, AFB1 is positive there is hepatocarcinoma in 5% of group 12 ; But HHBV positive, AFB1 positive group 52 9% find the hepatocarcinoma. Besides yellow aspergillus toxin, glutinous millet mould, variegated aspergillus, toxin that is dark and blue and green and mould have certain carcinogenic function.
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