general knowledge of liver cirrhosis

general knowledge of liver cirrhosis
Liver cirrhosis (liver cirrhosis) It is a kind of common chronic hepatopathy, can be caused the liver to damage by one or more reasons, the liver presents going on, filling the air, fiber pathological change. Embodied in the intersection of hepatocyte and the intersection of sex change and necrosis of filling the air etc., then appear fiber organize hyperplasia and the intersection of hepatocyte and the intersection of tubercle and the intersection of form and regeneration, these three kinds of changes interlocked and went on repeatedly, liver little leaf structure and blood circulation route were reconstructed gradually finally, deform liver, hard and cause liver cirrhosis. Disease this can have obvious symptom early period, a series of portal vein high pressure and liver function obstacle at various degrees appear on later stage, the upper digestive tract bleeds until appearing, liver complication death of encephalopathy,etc..
Cause of disease and having illness coming on in the mechanism
The cause of disease of liver cirrhosis is numerous, the following factors can cause liver cirrhosis.
1.Virus hepatitis At virus hepatitis of our country ' Especially B-mode and C-mode) It is a main reason for causing liver cirrhosis, among them the majority develops into pulse liver cirrhosis of the door. The liver cirrhosis patient's hepatocyte often shows HBsAg positively, its positive rate is up to 76.7%.
2.Chronic alcoholism can take total number at liver cirrhosis caused by alcohol hepatopathy of American-European countries 60% - 70% .
3.Alimentary deficiency animal's experiment shows, feeds the animal which lacks the choline or methionine food, can develop into liver cirrhosis through fatty liver.
4.The poisonous substance can cause liver cirrhosis while poisoning some chemical poisonous substance such as arsenic, tetrachloromethane, yellow phosphorus,etc. and acting on the liver for a long time.
5.Medicine hepatitis liver cirrhosis, it can cause liver cirrhosis to take some medicines harmful to liver for a long time
The mechanism is a going on fiber that liver cirrhosis mainly has illness coming on. The normal liver is organized collagen (I and type) of a quality Mainly distributed around area under control on the door and central vein. I type obviously increases and calm in the small leaf with the collagen at the time of liver cirrhosis. With the intersection of sinus and the intersection of crack and inner constant deposition of collagen, endothelial cell window Kong Ming apparent to reduce, make the liver sinus develop into the capillary gradually, cause the material exchange obstacle among blood and hepatocyte. A large number of collagen of liver cirrhosis comes from lying in the crack (Disse) of sinus Store lipoprotein cell (Ito cell) ,This cell increases life to jump, can transform into one kind of cells of fibrous master cell. Outgrowth fiber organize, form light pieces of Suo, connect, form interval and reconstruct the intersection of liver and little leaf at the structure each other yet initial stage, called the liver fiber. If continue developing, the central district of small leaf will connect with the fibrous interval of places such as the area under control of the door,etc. each other, make the little leaf structure of liver and blood circulate and reconstruct and form liver cirrhosis.
Liver cirrhosis classification
The same cause of disease can develop into liver cirrhosis of different pathologic types.
Classify by pathologic shape, can divide into little nodular liver cirrhosis, great nodular liver cirrhosis, liver cirrhosis of mixing etc., at all separating liver cirrhosis.
Classifying by cause of disease can be divided into virus hepatitis and liver cirrhosis, alcohol liver cirrhosis, supersession liver cirrhosis, bile depositing liver cirrhosis, liver intravenous reflux blockage liver cirrhosis, one's own immunity liver cirrhosis, poisonous substance and medicine liver cirrhosis, latent original liver cirrhosis, congenital syphilis liver cirrhosis, malnutritive liver cirrhosis.
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