The biological complex treatment of hepatocarcinoma is _'s treatment of the direction

The biological complex treatment of hepatocarcinoma is _'s treatment of the direction
The statistics show, the morbidity of hepatocarcinoma of Guangdong has already been up to 4% at present, is higher than the average national level. Recently, on surgical new technology forum of the liver of Guangdong Province that the first affiliated hospital of Guangzhou medical college sponsors, the academician of Chinese Academy of Engineering, soup of chief of research institute hepatocarcinoma of Fudan University encourage the trend that Professor You has introduced hepatocarcinoma treatment from the biological angle.
The soup encourages You to point out, close to one century in the past, the treatment of hepatocarcinoma of medical circle was set up on the pathological basis. Pathology main research cancer cell, the goal of the treatment is to eliminate tumour, cancer cell, mainly have surgery, radiotherapy, chemotherapy, the part is treated, treatment means of getting involved and treating etc., and tumour in order to control is always efficient to come as the index of appraising therapeutic method.
"By the 1990s last century, biology began to influence the hepatocarcinoma treatment too, the present treatment had pathology and biological characteristic concurrently. Stand on the biological angle looking, the target of studying in treatment of cancer is not merely a cancer cell, but the whole made up of organism hereditary condition, internal microenvironment and cancer cell, appraise one therapeutic method from biological angle, it depends on total life cycle in patient, include the patient's time to take tumour to survive. Molecule target biological main application means of to treat, not immune gene therapy,etc.. "
The biological angle is seen and examined and managed early early: The operation can not solve the problem completely
Soup encourage You say, examine, cure, make operation excise the intersection of result and rise greatly of hepatocarcinoma undoubtedly early early. Exceed 3 or two the intersection of cancer and the intersection of tubercle and diameter single the intersection of cancer and the intersection of tubercle and most large diameter at the clinic and hepatocarcinoma under 3 centimetres is called light hepatocarcinoma, it perform the operation at present kinds of patient on the five year last 57.3% survival rate already after excising,but if,etc. develop until big hepatocarcinoma finding by conditioning and excising operation, survival rate is only 30.9% in five years.
But he points out, the operation was excised for five years of hepatocarcinoma survival rate has already been close to the high limit, the space improved does not seem big. Take little hepatocarcinoma excision which the research institute of hepatocarcinoma of Fudan University has made as examples, 5 only 1/3 of survival rate between 1974 and 1958, and was up to 55.2% from 1974 to 1989. "But from 1989 to 2005, figure this rise several percentage point only, explain surgery, excise little therapeutic effect of hepatocarcinoma, already close to their high limits, other therapeutic method such as radio frequency, liver transplantation,etc. has met this question too. " He still shows, there are very high invasion and attack, transformation or latent energy of recuring even if it is small hepatocarcinoma, " the reason why examine and manage and can't solve the problem completely early early " .
Biological angle think cancer attack shift: The cancer cell is possible " Turn respectable "
So, the soup encourages You to think, in view of biological angle, there should be higher requirements in the hepatocarcinoma treatment, should direct against tumour, should direct against residual tumour cells too, " hepatocarcinoma is some pathological change, it is pathological change of the whole body even more, it is a long-term therapeutic direction that the ones that give consideration to patient's nerve, endocrine, supersession, immune system will be treated synthetically all over. "
The transformation of cancer lets many tumour patients and relatives strike torror at the mere mention of it, but the soup encourages You expressed, the medical circle utilizes a model system of metastasis of cancer of liver set up in 12 years to find, the microenvironment in laboratory little mouse's body can obviously change the biological characteristic of cancer, "it means cancer may make the condition deteriorate to shift to attack, may make the condition become well too, complex treatment in the future expected to can let cancer cell that shift ' turn respectable '. " He says, complex treatment different modes are still at at the beginning at present at the same time, there are still relatively few ones that were proved through following medical science of card, but it will be the trend that the future will be studied to study complex treatment from the biological angle.
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