Hepatocarcinoma postoperative diagnosis and countermeasure _'s treatment of recuring

Hepatocarcinoma postoperative diagnosis and countermeasure _'s treatment of recuring
It influences one of patient's curative effect of hepatocarcinoma and key obtained, survived for a long time that the recurring of hepatocarcinoma is shifted, already become at present, also the focus that hepatocarcinoma at present studies. OK when tumour predicted the emergence of the metastasis of cancer of liver and just sprouted in the clinical little transformation cooking stove before shifting, can make early diagnosis; Look for more effective prevention to shift and take place and treat the small method to shift cooking stove at the same time, it is a clinical subject to be solved urgently at present. In recent years, domestic and foreign to act as, study more, sketch it as follows to this.
First, rate and influence factor of recuring
The materials that I go over indicate, the recuring rate is 61.5% in 5 after hepatocarcinoma is excised, small hepatocarcinoma is 43.5% ( 1) . AFP is positive before we analyze 308 skills in recent years, hepatocarcinoma excised postoperative AFP and dropped to the normal case (belong to the effecting a radical cure excision comparatively reliable) ,1,3,5,The recuring rate is in 10 respectively 9.2%, 38.8%, 54.1%, 85.0%. It shows to compare and recur and recur a group of materials: General survey is found, - valley ammonia acyl is transferred to peptide enzyme ( - GPT) The value is relatively low, TNM by stages early and the intersection of tumour and body less than or equal to 5 cm, portal vein have the intersection of cancer and bolt, complement 6 index low main factor ( 2) of recuring etc. with immunization therapy,etc. while being postoperative .
The second, inferior and clinical one that recur and shift makes a diagnosis and gives treatment
It is basically similar that hepatocarcinoma excises the postoperative inferior clinical discovery route that recurs to shift and treats principle and inferior clinical hepatocarcinoma. It is extremely important to follow up a case by regular visits to postoperative fixedly and for a long time. Usually reexamine once every 2- 3 months in 2 years after the operation, reexamine once every 3- 6 months later, reexamine, include AFP mainly, Ultrasonography B, the intersection of X-ray and the intersection of chest and slice, make CT if necessary, MRI,etc.. It is the main therapeutic method ( 3) to and then perform the operation . Hepatocarcinoma of our institute recurs and excises again (202) The survival rate of the next 5 years is 35.4%, survival rate is 56.0% in 5 such as calculating from postoperative the first time. The isolatism lung shifts the cancer operation to excise (8) And then survive for 5 months of 10 (from 8 months to 6 months of 19) on average ,If survived for 2 months of 13 (one year and 4 months until 9 months of 23) on average from the moment that the first hepatocarcinoma is calculated after excising . In that it is 23 years and 9 months, 23 years ( 4) that 3 example persons who shifts lung still survive respectively so far . So, recur and shift cancer and excise and play an important role in further improving the curative effect of hepatocarcinoma again.
Third, shift animal's model and cell one
Study hepatocarcinoma and recur and shift, there should be model and cell one of animal's metastasis of cancer of people's liver at first. The efforts for many years that I have passed, have set up the model of naked mouse's metastasis of cancer of people's liver at first at home and abroad and already spread more than 70 generations, still keep shifting the characteristic ( 5) . Set up the high transformation latent energy cell one of people's hepatocarcinoma at first at the same time, has already spread more than 70 generations, have offered the valuable model for studying the metastasis of cancer of liver.
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