Epidemiology of hepatocarcinoma and summing up _'s general knowledge

Epidemiology of hepatocarcinoma and summing up _'s general knowledge
Hepatocarcinoma established its scientific pathology to classify, already have a history of one hundred years since the end of the 19th century. But it is very little that the more than half centuries of in the front develop, clarified in the fifties the structure was dissected in the liver, cause the birth of the systematicness excision of hepatocarcinoma; The setting-up that the liver cancer cell was in the sixties, discovery of B-mode hepatitis virus and aflatoxin, especially first child albumen (AFP) The detection in patient's blood of hepatocarcinoma, add success of liver transplantation,etc., has established the foundation of developing in recent years.
The seventies because AFP was measured and used in crowd's general survey, made the clinical research of hepatocarcinoma enter inferior clinical stage, survival rate is reached in 5 after small hepatocarcinoma is excised 60% - 70% , And cause the renewal of a series of concept of hepatocarcinoma diagnosing, treating, natural course of disease,etc.; Appearance of various new localization diagnostic methods charactered by the electronic computer is combined with new technology in the eighties, if electronic computer X-ray body layer scans (CT) , it is like (MRI) that the magnetic resonance is apparent , supersound apparent to show like the intersection of liver and the intersection of artery and radiography, radioactive nuclide alike, enable, diagnose competence raise obviously, add of different some therapeutic method application, make a portion in the unable hepatocarcinoma that excise to may walk dwindle, the past 2 issues excise, survival rate can match in excellence or beauty with the low person who excises hepatocarcinoma this the second stage of 5 when excised.
In research of the basic theory, have also achieved great success in the eighties, especially molecular biology respect. B-mode hepatitis virus (HBV) Have already obtained more evidences with the hepatocarcinoma relation, has found HBV-DNA can activate some cancer genes to combine, find tumour inhibits the disappearance of the gene from relating to emergence of hepatocarcinoma, finding a kind of hyperplasia of liver adenoma much can be developed into hepatocarcinoma. Find the liver has single centres that happens, also have many centre origins by molecular biological means. With link first acid,etc., already may turn, go against the intersection of liver and cancer cell.
In the eighties, represented by two international hepatocarcinoma hepatitis meetings in Shanghai of 1986 and 1991, have reflected the disparity of basic research of hepatocarcinoma and international most advanced level of our country is obviously shortened, have reflected the clinical research of hepatocarcinoma of our country had already formed the characteristic and has been paid attention to by international academia, international cancer two hepatocarcinoma divide into groups, have scholars of our country let the executive chairman to get the clear proof in the conference on the 15th 1990.
Primary hepatocarcinoma high to take place on the intersection of Africa and the southeast and Southeast Asia, our country see more southeast to be coastal. In terms of mortality, hepatocarcinoma of our country is the third cancer, 110,000 people die of hepatocarcinoma every year, men 80,000 among them, women 30,000, accounts for 45% of the death toll of hepatocarcinoma of whole world. The high trend that take place of hepatocarcinoma of our country is very severe, this is because there are persons who carries 120 millionHBV in our country, but take place to look in Jiangsu, Fujian, Guangdong, Guangxi,etc. high from hepatocarcinoma of our country, the coastal environmental factor in the southeast, for instance yellow aspergillus toxin and drinking the water pollution,etc. also plays an important role in the morbidity of hepatocarcinoma.
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